(r,r)-(-)-n,n′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(ii)

Description

The compound with the CAS number 176763-62-5 is a chiral cobalt coordination complex known as (R,R)-(-)-N,N′-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II), commonly referred to as (R,R)-Co(salen).

(R,R)-Co(salen) is a unique cobalt complex featuring a chiral ligand derived from 3,5-di-tert-butylsalicylaldehyde and 1,2-cyclohexanediamine. The complex exhibits a distinctive structure with two chiral centers, imparting a chirality to the central cobalt ion. This chirality plays a crucial role in its applications in catalysis and asymmetric synthesis.

In the field of catalysis, (R,R)-Co(salen) is widely employed as a versatile catalyst in various organic reactions, particularly in asymmetric transformations. Its chiral environment allows for efficient enantioselective catalysis, leading to the formation of optically active compounds with high enantiomeric excess. This property makes it a valuable tool in the synthesis of chiral pharmaceuticals and other bioactive compounds.

The coordination complex also displays interesting magnetic properties, contributing to its study in the field of molecular magnetism. The combination of the chiral ligands and the cobalt center leads to intriguing magnetic behavior, making (R,R)-Co(salen) an exciting subject of research in the development of molecular magnetic materials.

(R,R)-Co(salen) is a valuable compound in both academic research and industrial applications. Its chiral nature and catalytic properties have significant implications in the synthesis of complex molecules, offering new possibilities in the design of efficient and sustainable chemical processes. Additionally, its magnetic features hold promise in the development of advanced magnetic materials and molecular devices.

As with any chemical compound, proper handling and safety precautions should be observed when working with (R,R)-Co(salen). It is essential to follow good laboratory practices and adhere to relevant safety guidelines to ensure safe and successful research and applications of this unique coordination complex.

Features

❶ Chirality: (R,R)-Co(salen) possesses chirality due to the presence of two chiral centers in its ligand structure. This property makes it an excellent candidate for asymmetric catalysis, enabling the formation of enantiopure products with high stereoselectivity.

❷ Versatile Catalyst: As a cobalt coordination complex, (R,R)-Co(salen) serves as a versatile catalyst in various organic reactions. Its chiral environment allows it to catalyze asymmetric transformations, facilitating the synthesis of optically active compounds.

❸ Enantioselective Catalysis: The chiral ligands in (R,R)-Co(salen) lead to efficient enantioselective catalysis, enabling the selective synthesis of specific enantiomers in asymmetric reactions.

❹ Magnetic Properties: Apart from its catalytic applications, (R,R)-Co(salen) exhibits intriguing magnetic properties, making it a subject of interest in the field of molecular magnetism.

❺ Applications in Asymmetric Synthesis: Due to its high enantioselectivity, (R,R)-Co(salen) finds applications in the synthesis of chiral pharmaceuticals, natural products, and other bioactive compounds with potential applications in the pharmaceutical and agrochemical industries.

❻ Research Interest: The unique combination of chirality and magnetic properties makes (R,R)-Co(salen) an exciting area of research in molecular magnetism, material science, and asymmetric catalysis.

❼ Industrial and Academic Applications: (R,R)-Co(salen) has relevance both in academic research and industrial applications, particularly in the development of efficient and sustainable chemical processes for the synthesis of valuable chiral compounds.

Applications

1. Asymmetric Epoxidation

(R,R)-Co(salen) is a highly effective catalyst in the asymmetric epoxidation of olefins. It promotes the selective formation of chiral epoxides from simple olefin substrates, enabling the synthesis of valuable intermediates for the preparation of pharmaceuticals and fine chemicals.

2. Asymmetric Allylic Oxidation

It catalyzes the asymmetric allylic oxidation of allylic alcohols to form chiral enones and ketones with excellent enantioselectivity. These products are important building blocks in the synthesis of complex natural products and bioactive compounds.

3. Asymmetric Aminohydroxylation

(R,R)-Co(salen) is used in the asymmetric aminohydroxylation of olefins, providing a direct route to chiral amino alcohols, which are important in the synthesis of pharmaceuticals and other biologically active molecules.

4. Asymmetric Cyclopropanation

It promotes the asymmetric cyclopropanation of olefins with diazo compounds, affording chiral cyclopropanes that are versatile synthetic intermediates in organic chemistry.

5. Asymmetric Aziridination

(R,R)-Co(salen) catalyzes the asymmetric aziridination of olefins, leading to the formation of chiral aziridines, which are valuable building blocks for various chemical transformations.

6. Asymmetric Diels-Alder Reaction

It enables the asymmetric Diels-Alder reaction of dienes and dienophiles, providing enantioenriched cyclohexene derivatives.

7. Other Asymmetric Reactions

(R,R)-Co(salen) has also been explored in other asymmetric reactions, such as asymmetric desymmetrization, cycloadditions, and cascade reactions, expanding its utility in synthetic chemistry.

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Specifications

Product Name	(R,R)-N,N′-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminatocobalt(II)
Cas No.	176763-62-5
Molecular Formula	C36H52CoN2O2
Molecular Weight	603.76
Appearance	Red-brown powder
Purity	98% Min
Melting point	>350 °C(lit.)

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Storage

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Keep in dark place,Inert atmosphere,Room temperature

Package

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50kg/bag or as per your particular request.

Chiral Catalysts & Ligands

(R,R)-(-)-N,N′-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II) CAS 176763-62-5